Thermo Scientific Cryostats

Used & Refurbished Thermo Scientific Cryostats

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Thermo Scientific Microm CryoStar NX50 Cryostat MicrotomeThermo Scientific Microm CryoStar NX50 Cryostat Microtome
Cryostat, Research Grade

Thermo Scientific Microm CryoStar NX50 Cryostat Microtome

Learn more about the CryoStar NX50's features, testing process, and applications.

Thermo Microm HM 550 VP Cryostat Microtome 115V with VacutomeThermo Microm HM 550 VP Cryostat Microtome 115V with Vacutome
Cryostat, Research Grade

Thermo Microm HM 550 VP Cryostat Microtome 115V with Vacutome
Item No. 29101

Chamber: -10°C to -35°C

Specimen: +10°C to -50°C

Fine sectioning: 1 to 100 µm

Trim sectioning: 5 to 500 µm

Sale price$8,125.00
Thermo Scientific Microm HM 550 P 956424 Microtome CryostatThermo Scientific Microm HM 550 P 956424 Microtome Cryostat
Cryostat, Research Grade

Thermo Scientific Microm HM 550 P 956424 Microtome Cryostat
Item No. 28073

Chamber: -10°C to -35°C

Specimen: +10°C to -50°C

Fine sectioning: 1 to 100 µm

Trim sectioning: 5 to 500 µm

Sale price$8,125.00
Thermo Scientific Microm HM 550 P Microtome Cryostat 956424Thermo Scientific Microm HM 550 P Microtome Cryostat 956424
Cryostat, Research Grade

Thermo Scientific Microm HM 550 P Microtome Cryostat 956424
Item No. 27672

Chamber: -10°C to -35°C

Specimen: +10°C to -50°C

Fine sectioning: 1 to 100 µm

Trim sectioning: 5 to 500 µm

Sale price$8,125.00
Thermo Scientific Microm HM 550 VP Cryostat Microtome 956444 with VacutomeThermo Scientific Microm HM 550 VP Cryostat Microtome 956444 with Vacutome
Cryostat, Research Grade

Thermo Scientific Microm HM 550 VP Cryostat Microtome 956444 with Vacutome
Item No. 27671

Chamber: -10°C to -35°C

Specimen: +10°C to -50°C

Fine sectioning: 1 to 100 µm

Trim sectioning: 5 to 500 µm

Sale price$8,125.00
Thermo Scientific Microm HM 550 VP Cryostat Microtome with VacutomeThermo Scientific Microm HM 550 VP Cryostat Microtome with Vacutome
Cryostat, Research Grade

Thermo Scientific Microm HM 550 VP Cryostat Microtome with Vacutome
Item No. 28240

Chamber: -10°C to -35°C

Specimen: +10°C to -50°C

Fine sectioning: 1 to 100 µm

Trim sectioning: 5 to 500 µm

Sale price$8,125.00
Thermo Scientific Microm HM550 PO Cryostat MicrotomeThermo Scientific Microm HM550 PO Cryostat Microtome
Cryostat, Research Grade

Thermo Scientific Microm HM550 PO Cryostat Microtome

Learn more about the Microm HM550 PO's features, testing process, and applications.

Used Thermo Fisher Scientific Cryostats

Before selling its anatomical pathology division to PHC Holdings Corporation in early 2019, Thermo Fisher was one of the largest manufacturers of histology equipment. With two flagship cryostat brands, Microm and Shandon, Thermo offered both premium and budget-friendly sectioning options.

Now, going on two years after the sale to PHC, Thermo cryostats can still be easily found on the used market -- and they're still in high demand.

If you're in need of a "new" cryostat, read below for the details on Thermo's cryostats and what the used market landscape looks like for them.

Types of Thermo Cryostats

Some other cryostat manufacturers, such as Leica, offer both standard floor cryostats and portable benchtop cryostats. Thermo only supplies floor cryostats; however, there is a lot of variance between the models. We'll expound on Thermo's offerings below.

Notable Product Lines

Thermo had two separate brand of cryostats: Microm and Shandon. Because of the disparities in featureset, user experience, and price, it's clear that each brand was geared for different customer demographics.

Microm

Simply put, Microm is geared for power users, or at least frequent users. These units offer a premium sectioning experience and have all the bells 'n whistles you could need. In fact, Microm cryostats offer the best user experience of any brand, from any manufacturer, that we've had through here at New Life Scientific. Additionally, Microm is the only brand common on the used market that offers height adjustment in some models.

All of these niceties come at a cost, of course. Microm cryostats are significantly more expensive than Shandon, but if you're going to be slicing a lot or have complex requirements, the added costs will definitely be worth it. Older Microm units, such as the HM550, can typically be purchased between $6,000 and $8,000 used. Newer models like the CryoStar NX70 are available anywhere from $15,000 to $20,000 used.
Shandon

Shandon cryostats were designed with budget-conscious, no-nonsense buyers in mind. They're of acceptable quality but don't offer as many features as Microm units -- and their prices reflect that. You can purchase tested, serviced Shandon cryostats between $2,500 and $4,500.

If you have a lighter microtomy workload and simpler needs, then a Shandon system would work well for you.

Why Buy a Used Thermo Cryostat?

  • Lower costs: Used lab equipment is considerably cheaper (oftentimes over 50% off) than new, even when the differences between a used system and a new system are minimal. This is especially true of cryostats and, given that they're designed to last a long time, even a 10+ year old cryostat can still deliver a good ROI.
  • Eco-friendly: By supporting the used instrumentation economy, you're helping us extend the life of perfectly functional instruments and keep them out of landfills.

Why Buy from New Life Scientific?

Given our experience with cryostats and refrigeration systems, we offer an extensive degree of service and testing. Our team always makes sure to restore common failure points, like peltiers and refrigeration lines, back to their original functionality.

What to Look For in a Used Thermo Cryostat

  • Warranty: Used equipment isn't always sold by trustworthy dealers. They might say a cryostat is "working great", but when it stops working in a month, you're out of luck. Here at New Life Scientific, most of our products come with a 90-day warranty, and we go above and beyond to deliver equipment that works. In addition to our standard 90-day warranty, we also offer extended 120-day and 1-year warranties on some items.
  • Features: Certain Thermo cryostats have variate models based on the features they have, like a vacutome, UV disinfection, etc. You'll need to have a good understanding of the features you most need, then search out the corresponding models. Not all HM550s are equal!
  • Blade Holder Type: Permanent or disposable? This question is answered by your use case, so you'll want to make sure the cryostat you buy has a blade holder that will fit your needs.
  • Age: There are certain models that you should avoid simply because of how old they are, like the Microm HM 500, Microm HM 505/E, and older Cryotome E units.

    Pro Tip: Don't buy an HM560. They are prone to failure and difficult to repair.


 

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Prabin Dahal

Martin Fish Company

"...Great service and dedicated representatives! New Life Scientific will be my first choice if I need to purchase used/refurbished lab equipment."

Julia Zhang, Ph.D.

Aspire Pharma, Pharmaceutical Development

"...We are not only getting a quality equipment with competitive price and fast shipping, but also all the technical support we need to install and trouble shoot the equipment."

Dr. Xhavit Zogaj

UTSA, Department of Molecular Microbiology and Immunology

"They helped me find the right ultracentrifuge for our lab; and they were very efficient completing on time the purchase and delivery."

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Research Associate, Novome Bio

"These guys are the best and definitely my go to for used lab equipment now!"

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MD, Ph.D, University of Georgia

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Kurt Lamour

University of Tennessee Institute of Agriculture

"I buy quite a lot of used genetic analysis equipment from diverse vendors and would rarely dole out 5 stars. These folks earned it and I look forward to working with them in the future!"

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Genetic Assays, Inc. Director of Research and Laboratory Services/Vice President

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PATHOdiagnostics AG

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Thermo Scientific Cryostat FAQs

Select CryoStar NX70 models include built-in disinfection systems that use chemical fogging to reduce microbial contamination between users or sample types. This is valuable in clinical pathology labs and in research settings where cross-contamination could compromise results.

The cold disinfection feature supplements regular cleaning but does not replace manual decontamination. Many older or more basic Thermo models, such as Shandon units, may lack these capabilities, though labs can use portable units as an alternative. When evaluating a used Thermo cryostat, verify whether the unit has cold disinfection technology, as this feature may not be standard.

Thermo cryostats can handle fresh, fixed, OCT-embedded and fatty tissues, though each requires different approaches. Fresh frozen tissue can be sectioned well with careful temperature control to help prevent tearing. Fixed tissue that has been cryoprotected typically cuts effectively and maintains strong morphology. OCT-embedded specimens are standard for histology work and often section well on Thermo units.

Fatty tissue can be challenging, as adipose samples tend to compress, often requiring colder chamber temperatures and sharp blades. Thermo cryostats typically offer adjustable chamber temperatures, providing flexibility for different tissue varieties. Harder tissues, such as bone, are far from ideal for a cryostat and should be processed on a hard-tissue microtome.

Thermo cryostats use different blade holder systems by model. The Microm HM550 and CryoStar NX70 series accommodate disposable and permanent blade holders. Disposable holders accept standard low-profile blades and eliminate sharpening needs. Permanent holders use reusable steel blades that can be resharpened, helping users save money in high-volume labs. This increases the need for ongoing maintenance.

The Shandon Cryotome line uses a different configuration, so verify compatibility when switching brands. When purchasing a used Thermo cryostat, confirm which blade holder type is included and whether you need additional holders to match your desired setup.

Turn off the cryostat and allow the chamber to warm to room temperature. Once defrosted, remove specimen chucks, blade holders and accessories. Wipe down all interior surfaces with mild disinfectant or 70% ethanol, paying special attention to the specimen head, blade area and crevices where tissue fragments can hide. Remove and disinfect antiroll plates or specimen supports separately.

Refrain from using harsh solvents that could harm seals or painted surfaces. Dry all surfaces thoroughly to prevent ice buildup when restarting. If you are switching between sample types that could result in cross-contamination, use a more rigorous disinfection protocol. Contact our team if you need additional guidance on maintaining used equipment.

Buy & Sell Equipment at New Life Scientific

Since 2014, New Life Scientific has been your trusted source for quality used lab equipment across multiple disciplines. Our commitment to transparency and expert support means you can shop with confidence. Whether you're looking for a specific instrument or building out your entire lab setup, our large selection of equipment from leading manufacturers makes it easy to find what you need in one place. Shop online or contact our specialists to discuss your unique requirements.