Genizer Online Liposome Extruders can be connected with a sanitary pump or high pressure homogenizer and are temperature controlled, from testing to manufacturing production of pharmaceutical liposomes for anti-cancer drugs. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Online Liposome Extruders are designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Online Liposome Extruder offers virtually no dead volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.
Performance Highlight
- No dead volume
- Online extruder can control the temperature of extrusion
Application
- Liposome extrusion; Sterile filtration
Specifications:
| Catalog No. |
GOE-25mL |
GOE-200mL |
GOE-1000mL |
GOE-8L |
GOE-20L |
|
Sample Size
|
25mL |
200mL |
1000mL |
8000mL |
20000mL |
| Cooling |
Jacketed |
Jacketed |
Jacketed |
Jacketed |
Jacketed |
| Dimensions (cm) |
10×10×8 |
13×13×9 |
18×18×10 |
30×25×25 |
45×40×30 |
| Weight |
1kg |
2kg |
5kg |
25kg |
90kg |
| Min. Sample Size |
5mL |
10mL |
100mL |
500mL |
1000mL |
| Application |
Liposome formulation up to production scale; Sterile filtration
|
| Max. Pressure |
1,200 psi-3,500 psi
|
| Temp. Limit |
80ºC (176ºF)
|
| Power Type |
High pressure pump or high pressure homogenizer
|
| Nano-membrane |
Track-etched membrane |
| Cleaning |
Flush to clean/CIP/SIP |
| Sterilization |
Whole unit autoclavable |
Standard Features:
|
Parts
|
1) Liposome Online Extruder
2) 10 pieces of 100nm membrane
|
| Filter Support |
Jacketed filter support with pagoda inlet and outlet
|
| Inlet Type |
UNF 1/4" high pressure coupling for GOE-25ml/200ml/1L; UNF 3/8" high pressure coupling for GOE-8L; UNF 9/16" high pressure coupling for GOE-20L
|
| Outlet Type |
UNF 1/4" high pressure coupling for GOE-25ml/200ml/1L; UNF 3/8" high pressure coupling for GOE-8L; UNF 9/16" high pressure coupling for GOE-20L
|
| Handle |
Handle for GOE-800mL, GOE-3000mL and GOE-10000mL
|
| Nano Membrane |
100nm track-etched polycarbonate membrane
|
| Compatibility |
Some parts are compatible with Lipex in Northern Lipids
|
| Product Material |
316L stainless steel, viton
|
| Material Standard |
Sanitary grade; compliant with FDA and GMP sanitary standards
|
| Warranty |
1 year against any manufacturing defects |
Option Features:
| Detector |
10,000psi sanitary pressure gauge with adaptor, pressure transducer, temperature transducer
|
| Power |
Sanitary high pressure piston pump/hand pump
|
| Inlet Type |
Tri-clamp or luer |
| Outlet Type |
Tri-clamp or luer |
| Nano Membrane |
30nm, 50nm, 80nm, 100nm, 200nm, 400nm, 800nm, 1um, 2μm, 5μm, 10μm track-etched membrane (25mm, 47mm, 90mm, 142mm, 293mm)
|
| Multi Extruder |
Parallel or series connection of multi-extruder
URS for Liposome Extruders System.doc
|
